August 14, The Return of the Native I've been reading and in a few cases re-reading some of the novels of Thomas Hardy in the last few years, and you'll even find a reference to one of them, Jude the Obscure, in my book Funnybooks. The punning title of this item, about my return to what I hope will be reasonably frequent posting, is taken from one of Hardy's most famous novels, a book that I haven't read yet. I expect to remedy that omission in the near future. Hardy's novels are far removed from any connection to comics and animation that I can think of, and maybe that's why I've been enjoying them so much.
Methylation is a biochemical process that builds neurotransmitters like dopamine and serotonin, produces energy, processes hormones, builds immune cells, turns genes on and off, synthesizes DNA, produces the protective coating on your nerves and transforms toxins into safer substances.
Chemically speaking, methylation describes the addition of a methyl group to a substrate source material thereby producing a new chemical.
Sometimes instead of simply adding a methyl group, some other atom or group in the substrate is replaced. Methylation happens in all the cells of your body distributing methyl CH3 groups to as many as 50 or more other chemical processes in the body.
Methylation depends on a number of vitamins and cofactors which must be present for adequate functioning — those include folate and vitamin B Each of these is a potential weak link which may hobble your methylation cycle because of deficient diet, genetic mutation, toxic exposure, high stress, virus, infection or any combination of those.
Every can of tuna, every plastic bag, Styrofoam cup, cleaning Communication barrier poor timing and consumer product you touch is introducing chemicals into your blood that were unknown years ago. Or maybe you have mercury containing dental fillings.
Methylation is catalyzed by enzymes which are fragile and easily damaged by toxins like heavy metals especially mercury. Here is a more understandable explanation of how Mercury may be related to vitamin B12 written by Christina Bolander-Gouaille: The monovalent cobalt atom in methyl B12 is readily oxidized by various compounds — for instance nitrous oxide.
This oxidation inactivates methioninsyntase MS which has then to be formed de novo. Mercury, as we know, does oxidize many compounds, logically also cobalt. This in turn is one explanation of why symptoms of mercury overload and vitamin Bdeficiency may be identical! There is also a second possible interaction between vitamin B12, and mercury.
High doses of vitamin B12, that overcome the block to some extent, has had sometimes stunning results in these conditions. The good news is this: Your body will begin responding healing within minutes to active B12 supplementation which bypasses the blocks caused by heavy metals, genetic errors polymorphismsstress, etc.
The bad news for some is this: The length of time it takes for you to recover your health will depend on how long it took for you to lose it, and your symptoms may worsen at first during startup. Still, active B12 therapy has a lot going for it — you can do it on your own without a doctor, the supplements are inexpensive, the risks are low and the results start to show quickly.
If your situation is complicated by heavy metal toxicity, there is a solution for that also called Frequent Dose Chelation which shares some of the same characteristics — also possible without a doctor using inexpensive supplements and carries low risk.
One of the key diagnostics for chronic fatigue is exercise intolerance.
What do those of us cursed with exercise intolerance experience? We pay a terrible penalty for exercising; we become exhausted and may not move for several hours, we get thick brain fog and cognitive impairment, may feel flu-like, may feel anxious or jittery and have difficulty sleeping.
The next day, we continue to feel knocked-out and generally function at a low level. Chronic fatigue is the extreme case that probably helped researchers understand the impact of B12 deficiency and relationship with methylation cycle blocks. Just as there are many ways for B12 deficiency to express itself, there are multiple causes for B12 deficiency.
When a person is sitting on the edge, it can be triggered by any stress that challenges your biology significantly — whether by illness, injury, toxins or even a vaccination.
B12 deficiency can exist in the tissues independent of blood levels and also in the cerebrospinal fluid CSF independent of blood levels and tissue levels. There are two active forms of vitamin B12, of which, you may have a deficiency of either or both.
The two active forms of B12 are methylcobalamin also known as methylb12, mb12, mecob, mecbl and adenosylcobalamin also known as adenosylb12, adb12, adob12, cobamamide and dibencozide. Chemically, methylcobalamin is a co-enzyme for methionine synthase in the methylation cycle whose purpose is to convert homocysteine to methionine.
Adenosylcobalamin is a co-enzyme for methylmalonate CoA mutase which feed certain fuels into the Krebs cycle to help make ATP, a critical energy source in your body.
What are the 4 active deficiencies? There are two active b12s and there are two deficiency symptoms subsets syndromes for each one. There is the general body level deficiency of methylb12 and one of adenosylb There also are no mechanisms defined as to why some people have these depressed symptoms.
Those may come before I die of old age or not. A therapy based on those definitions is probably at least 50 years away. The Japanese are the only ones looking. In the meantime I have devised a pragmatic way of testing for such deficiencies and am getting close to being able to define the symptoms subsets of each.A1C A form of hemoglobin used to test blood sugars over a period of time.
ABCs of Behavior An easy method for remembering the order of behavioral components: Antecedent, Behavior, Consequence. Communication (from Latin commūnicāre, meaning "to share") is the act of conveying meanings from one entity or group to another through the use of mutually understood signs, symbols, and semiotic rules..
The main steps inherent to all communication are. The formation of communicative motivation or reason.; Message composition (further internal or technical elaboration on what exactly to. (4) Minimum requirements for audio description devices.. (i) A public accommodation shall provide at its movie theaters a minimum of one fully operational audio description device for every two movie theater auditoriums exhibiting digital movies and no less than two devices per movie theater.
Barriers to effective communication. Poor listening habits Inadequate knowledge of the subject Biases and stereotypes Lack of interest on the subject Personal opinions Interruptions Religious and cultural difference Language barrier Poor timing Guilt Status Benefits of effective communication.
Right information is shared Minimizes conflicts. Les Novros, Bill Hurtz, and Paul Julian sat for an interview with me at Julian's home in Van Nuys, California, in December This was a rarity among my interviews because three people (besides me) were talking for the tape recorder.
We talked at some length about their work for the Disney and. Article PDF. Introduction. The early s marked the first publications both in English studies and communication studies to address lesbian and gay issues.